Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-X-C chemokine receptor type 3/Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human)) | BDBM208742
(US9266876, 209)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2CN(C)CCc12)c1sc(nc1-c1nc2ccccc2[nH]1)C(F)(F)F Show InChI InChI=1S/C25H27F3N8OS/c1-15-11-34(9-10-36(15)20(37)13-35-14-29-18-12-33(2)8-7-19(18)35)23-21(32-24(38-23)25(26,27)28)22-30-16-5-3-4-6-17(16)31-22/h3-6,14-15H,7-13H2,1-2H3,(H,30,31)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the... |
US Patent US9266876 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80NB |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208742
(US9266876, 209)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2CN(C)CCc12)c1sc(nc1-c1nc2ccccc2[nH]1)C(F)(F)F Show InChI InChI=1S/C25H27F3N8OS/c1-15-11-34(9-10-36(15)20(37)13-35-14-29-18-12-33(2)8-7-19(18)35)23-21(32-24(38-23)25(26,27)28)22-30-16-5-3-4-6-17(16)31-22/h3-6,14-15H,7-13H2,1-2H3,(H,30,31)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00676
BindingDB Entry DOI: 10.7270/Q2222ZSK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208742
(US9266876, 209)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2CN(C)CCc12)c1sc(nc1-c1nc2ccccc2[nH]1)C(F)(F)F Show InChI InChI=1S/C25H27F3N8OS/c1-15-11-34(9-10-36(15)20(37)13-35-14-29-18-12-33(2)8-7-19(18)35)23-21(32-24(38-23)25(26,27)28)22-30-16-5-3-4-6-17(16)31-22/h3-6,14-15H,7-13H2,1-2H3,(H,30,31)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00676
BindingDB Entry DOI: 10.7270/Q2222ZSK |
More data for this
Ligand-Target Pair | |