Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3/Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human)) | BDBM208613
(US9266876, 80)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(Br)nc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C23H21BrN8OS/c1-14-11-30(9-10-32(14)18(33)12-31-13-26-17-7-4-8-25-21(17)31)22-19(29-23(24)34-22)20-27-15-5-2-3-6-16(15)28-20/h2-8,13-14H,9-12H2,1H3,(H,27,28)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the... |
US Patent US9266876 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80NB |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208613
(US9266876, 80)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(Br)nc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C23H21BrN8OS/c1-14-11-30(9-10-32(14)18(33)12-31-13-26-17-7-4-8-25-21(17)31)22-19(29-23(24)34-22)20-27-15-5-2-3-6-16(15)28-20/h2-8,13-14H,9-12H2,1H3,(H,27,28)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208613
(US9266876, 80)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(Br)nc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C23H21BrN8OS/c1-14-11-30(9-10-32(14)18(33)12-31-13-26-17-7-4-8-25-21(17)31)22-19(29-23(24)34-22)20-27-15-5-2-3-6-16(15)28-20/h2-8,13-14H,9-12H2,1H3,(H,27,28)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM208613
(US9266876, 80)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(Br)nc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C23H21BrN8OS/c1-14-11-30(9-10-32(14)18(33)12-31-13-26-17-7-4-8-25-21(17)31)22-19(29-23(24)34-22)20-27-15-5-2-3-6-16(15)28-20/h2-8,13-14H,9-12H2,1H3,(H,27,28)/t14-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208613
(US9266876, 80)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(Br)nc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C23H21BrN8OS/c1-14-11-30(9-10-32(14)18(33)12-31-13-26-17-7-4-8-25-21(17)31)22-19(29-23(24)34-22)20-27-15-5-2-3-6-16(15)28-20/h2-8,13-14H,9-12H2,1H3,(H,27,28)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 526 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |