Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3/Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human)) | BDBM208606
(US9266876, 73)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(nc1-c1nc2ccccc2[nH]1)C1CC1 Show InChI InChI=1S/C26H26N8OS/c1-16-13-32(11-12-34(16)21(35)14-33-15-28-20-7-4-10-27-24(20)33)26-22(31-25(36-26)17-8-9-17)23-29-18-5-2-3-6-19(18)30-23/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,29,30)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the... |
US Patent US9266876 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80NB |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208606
(US9266876, 73)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(nc1-c1nc2ccccc2[nH]1)C1CC1 Show InChI InChI=1S/C26H26N8OS/c1-16-13-32(11-12-34(16)21(35)14-33-15-28-20-7-4-10-27-24(20)33)26-22(31-25(36-26)17-8-9-17)23-29-18-5-2-3-6-19(18)30-23/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,29,30)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM208606
(US9266876, 73)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(nc1-c1nc2ccccc2[nH]1)C1CC1 Show InChI InChI=1S/C26H26N8OS/c1-16-13-32(11-12-34(16)21(35)14-33-15-28-20-7-4-10-27-24(20)33)26-22(31-25(36-26)17-8-9-17)23-29-18-5-2-3-6-19(18)30-23/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,29,30)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208606
(US9266876, 73)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(nc1-c1nc2ccccc2[nH]1)C1CC1 Show InChI InChI=1S/C26H26N8OS/c1-16-13-32(11-12-34(16)21(35)14-33-15-28-20-7-4-10-27-24(20)33)26-22(31-25(36-26)17-8-9-17)23-29-18-5-2-3-6-19(18)30-23/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,29,30)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 745 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM208606
(US9266876, 73)Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(nc1-c1nc2ccccc2[nH]1)C1CC1 Show InChI InChI=1S/C26H26N8OS/c1-16-13-32(11-12-34(16)21(35)14-33-15-28-20-7-4-10-27-24(20)33)26-22(31-25(36-26)17-8-9-17)23-29-18-5-2-3-6-19(18)30-23/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,29,30)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 994 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00675 BindingDB Entry DOI: 10.7270/Q29K4G85 |
More data for this Ligand-Target Pair | |