Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50200905
(CHEMBL3974827)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2cc(OCC(F)(F)F)ccc2[C@H](C)N1C(=O)Nc1cccnc1 |r| Show InChI InChI=1S/C26H27F3N4O2/c1-18-15-32(16-20-7-4-3-5-8-20)24-13-22(35-17-26(27,28)29)10-11-23(24)19(2)33(18)25(34)31-21-9-6-12-30-14-21/h3-14,18-19H,15-17H2,1-2H3,(H,31,34)/t18-,19+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM50200905
(CHEMBL3974827)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2cc(OCC(F)(F)F)ccc2[C@H](C)N1C(=O)Nc1cccnc1 |r| Show InChI InChI=1S/C26H27F3N4O2/c1-18-15-32(16-20-7-4-3-5-8-20)24-13-22(35-17-26(27,28)29)10-11-23(24)19(2)33(18)25(34)31-21-9-6-12-30-14-21/h3-14,18-19H,15-17H2,1-2H3,(H,31,34)/t18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1I
(Homo sapiens (Human)) | BDBM50200905
(CHEMBL3974827)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2cc(OCC(F)(F)F)ccc2[C@H](C)N1C(=O)Nc1cccnc1 |r| Show InChI InChI=1S/C26H27F3N4O2/c1-18-15-32(16-20-7-4-3-5-8-20)24-13-22(35-17-26(27,28)29)10-11-23(24)19(2)33(18)25(34)31-21-9-6-12-30-14-21/h3-14,18-19H,15-17H2,1-2H3,(H,31,34)/t18-,19+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |