Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50200889
(CHEMBL3897825)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2nc(C)ccc2[C@H](C)N1C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C26H30N4O/c1-19-14-15-24-21(3)30(26(31)27-16-22-10-6-4-7-11-22)20(2)17-29(25(24)28-19)18-23-12-8-5-9-13-23/h4-15,20-21H,16-18H2,1-3H3,(H,27,31)/t20-,21+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM50200889
(CHEMBL3897825)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2nc(C)ccc2[C@H](C)N1C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C26H30N4O/c1-19-14-15-24-21(3)30(26(31)27-16-22-10-6-4-7-11-22)20(2)17-29(25(24)28-19)18-23-12-8-5-9-13-23/h4-15,20-21H,16-18H2,1-3H3,(H,27,31)/t20-,21+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1I
(Homo sapiens (Human)) | BDBM50200889
(CHEMBL3897825)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2nc(C)ccc2[C@H](C)N1C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C26H30N4O/c1-19-14-15-24-21(3)30(26(31)27-16-22-10-6-4-7-11-22)20(2)17-29(25(24)28-19)18-23-12-8-5-9-13-23/h4-15,20-21H,16-18H2,1-3H3,(H,27,31)/t20-,21+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |