Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent T-type calcium channel subunit alpha-1I
(Homo sapiens (Human)) | BDBM50200817
(CHEMBL3934795)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2ncc(Cl)cc2[C@H](C)N1C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C25H27ClN4O/c1-18-16-29(17-21-11-7-4-8-12-21)24-23(13-22(26)15-27-24)19(2)30(18)25(31)28-14-20-9-5-3-6-10-20/h3-13,15,18-19H,14,16-17H2,1-2H3,(H,28,31)/t18-,19+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM50200817
(CHEMBL3934795)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2ncc(Cl)cc2[C@H](C)N1C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C25H27ClN4O/c1-18-16-29(17-21-11-7-4-8-12-21)24-23(13-22(26)15-27-24)19(2)30(18)25(31)28-14-20-9-5-3-6-10-20/h3-13,15,18-19H,14,16-17H2,1-2H3,(H,28,31)/t18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM50200817
(CHEMBL3934795)Show SMILES C[C@@H]1CN(Cc2ccccc2)c2ncc(Cl)cc2[C@H](C)N1C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C25H27ClN4O/c1-18-16-29(17-21-11-7-4-8-12-21)24-23(13-22(26)15-27-24)19(2)30(18)25(31)28-14-20-9-5-3-6-10-20/h3-13,15,18-19H,14,16-17H2,1-2H3,(H,28,31)/t18-,19+/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ... |
J Med Chem 59: 10661-10675 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01356 BindingDB Entry DOI: 10.7270/Q2RV0QN8 |
More data for this Ligand-Target Pair | |