Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50052885
((R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline | CHE...)Show InChI InChI=1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3/t8-/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase). |
J Med Chem 42: 4351-61 (1999)
BindingDB Entry DOI: 10.7270/Q2X0667W |
More data for this Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50052885
((R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline | CHE...)Show InChI InChI=1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3/t8-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor |
Bioorg Med Chem Lett 9: 481-6 (1999)
BindingDB Entry DOI: 10.7270/Q26Q20F9 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50052885
((R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline | CHE...)Show InChI InChI=1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3/t8-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) |
Bioorg Med Chem Lett 9: 481-6 (1999)
BindingDB Entry DOI: 10.7270/Q26Q20F9 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50052885
((R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline | CHE...)Show InChI InChI=1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3/t8-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyl transferase |
J Med Chem 42: 1982-90 (1999)
Article DOI: 10.1021/jm9807252 BindingDB Entry DOI: 10.7270/Q2959GR6 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50052885
((R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline | CHE...)Show InChI InChI=1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3/t8-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro for inhibition of Phenylethanolamine N-Methyltransferase (PNMT) |
J Med Chem 39: 3539-46 (1996)
Article DOI: 10.1021/jm9508292 BindingDB Entry DOI: 10.7270/Q2JM28RQ |
More data for this Ligand-Target Pair | |