Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM477890
(US10889579, Example 110)Show SMILES C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1 |t:5| Show InChI InChI=1S/C25H25F2N5O2S/c1-24(15-25(2,35-23(29)31-24)22(33)32-7-9-34-10-8-32)18-11-16(3-5-19(18)26)12-20(27)21-6-4-17(13-28)14-30-21/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,29,31)/b20-12-/t24-,25-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US10889579 (2021)
BindingDB Entry DOI: 10.7270/Q241715H |
More data for this Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM477890
(US10889579, Example 110)Show SMILES C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1 |t:5| Show InChI InChI=1S/C25H25F2N5O2S/c1-24(15-25(2,35-23(29)31-24)22(33)32-7-9-34-10-8-32)18-11-16(3-5-19(18)26)12-20(27)21-6-4-17(13-28)14-30-21/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,29,31)/b20-12-/t24-,25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... |
US Patent US10889579 (2021)
BindingDB Entry DOI: 10.7270/Q241715H |
More data for this Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM477890
(US10889579, Example 110)Show SMILES C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1 |t:5| Show InChI InChI=1S/C25H25F2N5O2S/c1-24(15-25(2,35-23(29)31-24)22(33)32-7-9-34-10-8-32)18-11-16(3-5-19(18)26)12-20(27)21-6-4-17(13-28)14-30-21/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,29,31)/b20-12-/t24-,25-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ... |
US Patent US10889579 (2021)
BindingDB Entry DOI: 10.7270/Q241715H |
More data for this Ligand-Target Pair | |