Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM214828
(US9296734, 28)Show SMILES C[C@]1(C[C@H](OC(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ccc(OCC#C)cn2)ccc1F |r,c:6| Show InChI InChI=1S/C21H18F4N4O3/c1-3-8-31-13-5-7-16(27-11-13)18(30)28-12-4-6-15(22)14(9-12)20(2)10-17(21(23,24)25)32-19(26)29-20/h1,4-7,9,11,17H,8,10H2,2H3,(H2,26,29)(H,28,30)/t17-,20-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | 37 |
Amgen Inc.
US Patent
| Assay Description The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM214828
(US9296734, 28)Show SMILES C[C@]1(C[C@H](OC(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ccc(OCC#C)cn2)ccc1F |r,c:6| Show InChI InChI=1S/C21H18F4N4O3/c1-3-8-31-13-5-7-16(27-11-13)18(30)28-12-4-6-15(22)14(9-12)20(2)10-17(21(23,24)25)32-19(26)29-20/h1,4-7,9,11,17H,8,10H2,2H3,(H2,26,29)(H,28,30)/t17-,20-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 17.6 | n/a | n/a | n/a | n/a | 4.2 | n/a |
Amgen Inc.
US Patent
| Assay Description The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM214828
(US9296734, 28)Show SMILES C[C@]1(C[C@H](OC(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ccc(OCC#C)cn2)ccc1F |r,c:6| Show InChI InChI=1S/C21H18F4N4O3/c1-3-8-31-13-5-7-16(27-11-13)18(30)28-12-4-6-15(22)14(9-12)20(2)10-17(21(23,24)25)32-19(26)29-20/h1,4-7,9,11,17H,8,10H2,2H3,(H2,26,29)(H,28,30)/t17-,20-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.66E+5 | n/a | n/a | n/a | n/a | 3.5 | n/a |
Amgen Inc.
US Patent
| Assay Description Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this Ligand-Target Pair | |