Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 2
(Homo sapiens (Human)) | BDBM259183
(US9499502, 27bs-a)Show SMILES C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccc1F)c1sc(cc1F)-c1cccc(c1)C#N |r| Show InChI InChI=1S/C23H19F2N3O2S2/c1-22(20-18(25)11-19(31-20)15-7-5-6-14(10-15)12-26)13-32(29,30)23(2,21(27)28-22)16-8-3-4-9-17(16)24/h3-11H,13H2,1-2H3,(H2,27,28)/t22-,23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 9 | -46.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM259183
(US9499502, 27bs-a)Show SMILES C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccc1F)c1sc(cc1F)-c1cccc(c1)C#N |r| Show InChI InChI=1S/C23H19F2N3O2S2/c1-22(20-18(25)11-19(31-20)15-7-5-6-14(10-15)12-26)13-32(29,30)23(2,21(27)28-22)16-8-3-4-9-17(16)24/h3-11H,13H2,1-2H3,(H2,27,28)/t22-,23-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 68.3 | -41.6 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |