Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 2
(Homo sapiens (Human)) | BDBM259121
(US9499502, 27p)Show SMILES C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc2nncn2c1 |r| Show InChI InChI=1S/C17H18ClN5O2S2/c1-16(2)15(19)21-17(3,8-27(16,24)25)14-11(18)6-12(26-14)10-4-5-13-22-20-9-23(13)7-10/h4-7,9H,8H2,1-3H3,(H2,19,21)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 600 | -36.1 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM259121
(US9499502, 27p)Show SMILES C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc2nncn2c1 |r| Show InChI InChI=1S/C17H18ClN5O2S2/c1-16(2)15(19)21-17(3,8-27(16,24)25)14-11(18)6-12(26-14)10-4-5-13-22-20-9-23(13)7-10/h4-7,9H,8H2,1-3H3,(H2,19,21)/t17-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 2.53E+3 | -32.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo... |
US Patent US9499502 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7FJJ |
More data for this
Ligand-Target Pair | |