Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 356.3 BDBM50052022

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50052022 ((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...) Show SMILES C[C@H](C([O-])=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 Show InChI InChI=1S/C23H19NO3/c1-15(23(25)26)18-7-6-16-9-11-21(13-19(16)12-18)27-14-20-10-8-17-4-2-3-5-22(17)24-20/h2-13,15H,14H2,1H3,(H,25,26)/p-1/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards Cysteinyl leukotriene D4 receptor antagonist in guinea pig lung membranes				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50052022 ((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...) Show SMILES C[C@H](C([O-])=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 Show InChI InChI=1S/C23H19NO3/c1-15(23(25)26)18-7-6-16-9-11-21(13-19(16)12-18)27-14-20-10-8-17-4-2-3-5-22(17)24-20/h2-13,15H,14H2,1H3,(H,25,26)/p-1/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in RBL-2H3 cells				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50052022 ((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...) Show SMILES C[C@H](C([O-])=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 Show InChI InChI=1S/C23H19NO3/c1-15(23(25)26)18-7-6-16-9-11-21(13-19(16)12-18)27-14-20-10-8-17-4-2-3-5-22(17)24-20/h2-13,15H,14H2,1H3,(H,25,26)/p-1/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS]				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50052022 ((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...) Show SMILES C[C@H](C([O-])=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 Show InChI InChI=1S/C23H19NO3/c1-15(23(25)26)18-7-6-16-9-11-21(13-19(16)12-18)27-14-20-10-8-17-4-2-3-5-22(17)24-20/h2-13,15H,14H2,1H3,(H,25,26)/p-1/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description The compound was tested for inhibitory activity against 5-lipoxygenase in human polymorphonuclear leukocytes[PMNS]				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
					More data for this Ligand-Target Pair