Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169380
(US9079866, 785 | US9745328, Compound 785 | US98848...)Show SMILES C[C@H](CO)NC(=O)c1cc(ccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F4N4O2/c1-11(10-30)29-20(31)16-7-13(21(23,24)25)3-5-14(16)12-2-4-15(17(22)6-12)18-8-28-19(26)9-27-18/h2-9,11,30H,10H2,1H3,(H2,26,28)(H,29,31)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM169380
(US9079866, 785 | US9745328, Compound 785 | US98848...)Show SMILES C[C@H](CO)NC(=O)c1cc(ccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F4N4O2/c1-11(10-30)29-20(31)16-7-13(21(23,24)25)3-5-14(16)12-2-4-15(17(22)6-12)18-8-28-19(26)9-27-18/h2-9,11,30H,10H2,1H3,(H2,26,28)(H,29,31)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169380
(US9079866, 785 | US9745328, Compound 785 | US98848...)Show SMILES C[C@H](CO)NC(=O)c1cc(ccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F4N4O2/c1-11(10-30)29-20(31)16-7-13(21(23,24)25)3-5-14(16)12-2-4-15(17(22)6-12)18-8-28-19(26)9-27-18/h2-9,11,30H,10H2,1H3,(H2,26,28)(H,29,31)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this Ligand-Target Pair | |