Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 502.9 BDBM300335

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM300335 (US9593110, 37-1) Show SMILES C[C@H](N)C(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O Show InChI InChI=1S/C23H24ClFN6O4/c1-12(26)21(32)29-19(23(34)35)10-16(28-22(33)20-11-27-31-30-20)8-13-2-4-14(5-3-13)17-9-15(24)6-7-18(17)25/h2-7,9,11-12,16,19H,8,10,26H2,1H3,(H,28,33)(H,29,32)(H,34,35)(H,27,30,31)/t12-,16+,19+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair