Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 322.4 BDBM185571

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM185571 (US9156845, 7) Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12 Show InChI InChI=1S/C19H22N4O/c1-13-4-3-7-23(10-13)19-17-16(9-20-18(17)21-12-22-19)15-6-2-5-14(8-15)11-24/h2,5-6,8-9,12-13,24H,3-4,7,10-11H2,1H3,(H,20,21,22)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM185571 (US9156845, 7) Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12 Show InChI InChI=1S/C19H22N4O/c1-13-4-3-7-23(10-13)19-17-16(9-20-18(17)21-12-22-19)15-6-2-5-14(8-15)11-24/h2,5-6,8-9,12-13,24H,3-4,7,10-11H2,1H3,(H,20,21,22)/t13-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair