Found 5 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM362842
((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)Show SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1cc(F)c(F)c(F)c1F |r| Show InChI InChI=1S/C18H14F4N4O2/c1-8-3-4-12(28-8)17-24-23-16-9(2)25(5-6-26(16)17)18(27)10-7-11(19)14(21)15(22)13(10)20/h3-4,7,9H,5-6H2,1-2H3/t9-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGED SA
US Patent
| Assay Description
The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra... |
US Patent US9840508 (2017)
BindingDB Entry DOI: 10.7270/Q2SQ92P6 |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM362842
((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)Show SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1cc(F)c(F)c(F)c1F |r| Show InChI InChI=1S/C18H14F4N4O2/c1-8-3-4-12(28-8)17-24-23-16-9(2)25(5-6-26(16)17)18(27)10-7-11(19)14(21)15(22)13(10)20/h3-4,7,9H,5-6H2,1-2H3/t9-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGED SA
US Patent
| Assay Description
The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra... |
US Patent US9840508 (2017)
BindingDB Entry DOI: 10.7270/Q2SQ92P6 |
More data for this
Ligand-Target Pair | |
Substance-K receptor
(Homo sapiens (Human)) | BDBM362842
((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)Show SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1cc(F)c(F)c(F)c1F |r| Show InChI InChI=1S/C18H14F4N4O2/c1-8-3-4-12(28-8)17-24-23-16-9(2)25(5-6-26(16)17)18(27)10-7-11(19)14(21)15(22)13(10)20/h3-4,7,9H,5-6H2,1-2H3/t9-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGED SA
US Patent
| Assay Description
The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra... |
US Patent US9840508 (2017)
BindingDB Entry DOI: 10.7270/Q2SQ92P6 |
More data for this
Ligand-Target Pair | |
Substance-P receptor
(Homo sapiens (Human)) | BDBM362842
((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)Show SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1cc(F)c(F)c(F)c1F |r| Show InChI InChI=1S/C18H14F4N4O2/c1-8-3-4-12(28-8)17-24-23-16-9(2)25(5-6-26(16)17)18(27)10-7-11(19)14(21)15(22)13(10)20/h3-4,7,9H,5-6H2,1-2H3/t9-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
OGED SA
US Patent
| Assay Description
The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra... |
US Patent US9840508 (2017)
BindingDB Entry DOI: 10.7270/Q2SQ92P6 |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM362842
((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)Show SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1cc(F)c(F)c(F)c1F |r| Show InChI InChI=1S/C18H14F4N4O2/c1-8-3-4-12(28-8)17-24-23-16-9(2)25(5-6-26(16)17)18(27)10-7-11(19)14(21)15(22)13(10)20/h3-4,7,9H,5-6H2,1-2H3/t9-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
OGED SA
US Patent
| Assay Description
The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra... |
US Patent US9840508 (2017)
BindingDB Entry DOI: 10.7270/Q2SQ92P6 |
More data for this
Ligand-Target Pair | |