Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132597
(US8841312, 346)Show SMILES C1CC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 Show InChI InChI=1S/C21H23N9/c1-2-14(3-1)30-17-13-23-7-6-15(17)16-12-24-21(26-20(16)30)25-18-4-5-19(28-27-18)29-10-8-22-9-11-29/h4-7,12-14,22H,1-3,8-11H2,(H,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132597
(US8841312, 346)Show SMILES C1CC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 Show InChI InChI=1S/C21H23N9/c1-2-14(3-1)30-17-13-23-7-6-15(17)16-12-24-21(26-20(16)30)25-18-4-5-19(28-27-18)29-10-8-22-9-11-29/h4-7,12-14,22H,1-3,8-11H2,(H,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |