Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132508
(US8841312, 257)Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3CCNCC3)nc12 Show InChI InChI=1S/C24H27N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-6,9,12-16,18,25H,1-4,7-8,10-11H2,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132508
(US8841312, 257)Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3CCNCC3)nc12 Show InChI InChI=1S/C24H27N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-6,9,12-16,18,25H,1-4,7-8,10-11H2,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |