Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132421
(US8841312, 168)Show SMILES C1CCC(C1)n1c2cnsc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 Show InChI InChI=1S/C21H24N8S/c1-2-4-14(3-1)29-17-13-25-30-19(17)16-12-24-21(27-20(16)29)26-18-6-5-15(11-23-18)28-9-7-22-8-10-28/h5-6,11-14,22H,1-4,7-10H2,(H,23,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132421
(US8841312, 168)Show SMILES C1CCC(C1)n1c2cnsc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 Show InChI InChI=1S/C21H24N8S/c1-2-4-14(3-1)29-17-13-25-30-19(17)16-12-24-21(27-20(16)29)26-18-6-5-15(11-23-18)28-9-7-22-8-10-28/h5-6,11-14,22H,1-4,7-10H2,(H,23,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |