Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 497.4 BDBM50001204

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50001204 (CHEMBL3236420) Show SMILES CC(=O)N1CCC[C@H]1C(=O)NP(S)(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O |r| Show InChI InChI=1S/C16H22F2N5O7PS/c1-8(24)22-5-2-3-9(22)13(26)21-31(28,32)29-7-10-12(25)16(17,18)14(30-10)23-6-4-11(19)20-15(23)27/h4,6,9-10,12,14,25H,2-3,5,7H2,1H3,(H2,19,20,27)(H2,21,26,28,32)/t9-,10+,12+,14+,31?/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs				Bioorg Med Chem 22: 2133-40 (2014) Article DOI: 10.1016/j.bmc.2014.02.034 BindingDB Entry DOI: 10.7270/Q20866TW
					More data for this Ligand-Target Pair