Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 431.4 BDBM289986

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289986 (1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benz...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1coc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc12 Show InChI InChI=1S/C23H21N5O4/c1-15(29)27-8-10-28(11-9-27)23(30)19-14-31-21-12-17(3-4-18(19)21)32-22-5-2-16(13-24-22)20-6-7-25-26-20/h2-7,12-14H,8-11H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
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