Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human)) | BDBM287659
(US10085984, Example 37 | US11040034, Ex. No. 37)Show SMILES CC(=O)N1CCN(CC1)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1 Show InChI InChI=1S/C20H20F2N6O/c1-12(29)26-4-6-27(7-5-26)19-8-13(11-23-25-19)20-24-17-9-15(21)16(22)10-18(17)28(20)14-2-3-14/h8-11,14H,2-7H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BV7KRW |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human)) | BDBM287659
(US10085984, Example 37 | US11040034, Ex. No. 37)Show SMILES CC(=O)N1CCN(CC1)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1 Show InChI InChI=1S/C20H20F2N6O/c1-12(29)26-4-6-27(7-5-26)19-8-13(11-23-25-19)20-24-17-9-15(21)16(22)10-18(17)28(20)14-2-3-14/h8-11,14H,2-7H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Viamet Pharmaceuticals (Bermuda), Ltd.
US Patent
| Assay Description V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t... |
US Patent US10085984 (2018)
BindingDB Entry DOI: 10.7270/Q2542QM2 |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human)) | BDBM287659
(US10085984, Example 37 | US11040034, Ex. No. 37)Show SMILES CC(=O)N1CCN(CC1)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1 Show InChI InChI=1S/C20H20F2N6O/c1-12(29)26-4-6-27(7-5-26)19-8-13(11-23-25-19)20-24-17-9-15(21)16(22)10-18(17)28(20)14-2-3-14/h8-11,14H,2-7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Viamet Pharmaceuticals (Bermuda), Ltd.
US Patent
| Assay Description V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t... |
US Patent US10085984 (2018)
BindingDB Entry DOI: 10.7270/Q2542QM2 |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human)) | BDBM287659
(US10085984, Example 37 | US11040034, Ex. No. 37)Show SMILES CC(=O)N1CCN(CC1)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1 Show InChI InChI=1S/C20H20F2N6O/c1-12(29)26-4-6-27(7-5-26)19-8-13(11-23-25-19)20-24-17-9-15(21)16(22)10-18(17)28(20)14-2-3-14/h8-11,14H,2-7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BV7KRW |
More data for this Ligand-Target Pair | |