Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM337887
(US9751854, Compound I-70 | US9802960, Compound I-7...)Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cccc(c2)C(C)(C)C)c1 Show InChI InChI=1S/C23H26N4O3S/c1-15-21(27-31(29,30)20-8-6-7-19(13-20)23(3,4)5)11-18(14-25-15)17-9-10-24-22(12-17)26-16(2)28/h6-14,27H,1-5H3,(H,24,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description 100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9802960 (2017)
BindingDB Entry DOI: 10.7270/Q2D79DJ9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human)) | BDBM337887
(US9751854, Compound I-70 | US9802960, Compound I-7...)Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cccc(c2)C(C)(C)C)c1 Show InChI InChI=1S/C23H26N4O3S/c1-15-21(27-31(29,30)20-8-6-7-19(13-20)23(3,4)5)11-18(14-25-15)17-9-10-24-22(12-17)26-16(2)28/h6-14,27H,1-5H3,(H,24,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
US Patent
| Assay Description 100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro... |
US Patent US9751854 (2017)
BindingDB Entry DOI: 10.7270/Q2KS6TNJ |
More data for this Ligand-Target Pair | |