Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
LIM domain kinase 1
(Homo sapiens (Human)) | BDBM50124351
(CHEMBL3623440)Show InChI InChI=1S/C16H12ClN3OS/c1-10(21)20-16-19-9-15(22-16)12-6-7-18-8-13(12)11-4-2-3-5-14(11)17/h2-9H,1H3,(H,19,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrate |
J Med Chem 58: 8309-13 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01242 BindingDB Entry DOI: 10.7270/Q27P917N |
More data for this Ligand-Target Pair | |
LIM domain kinase 1
(Homo sapiens (Human)) | BDBM50124351
(CHEMBL3623440)Show InChI InChI=1S/C16H12ClN3OS/c1-10(21)20-16-19-9-15(22-16)12-6-7-18-8-13(12)11-4-2-3-5-14(11)17/h2-9H,1H3,(H,19,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology
Curated by ChEMBL
| Assay Description Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrs |
J Med Chem 58: 8309-13 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01242 BindingDB Entry DOI: 10.7270/Q27P917N |
More data for this Ligand-Target Pair | |