Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human)) | BDBM50207407
(CHEMBL3936830)Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(Cl)c1O Show InChI InChI=1S/C21H16ClN5O4/c1-12(28)16-6-7-17(19(22)20(16)29)30-11-13-3-2-4-15(9-13)31-18-8-5-14(10-23-18)21-24-26-27-25-21/h2-10,29H,11H2,1H3,(H,24,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 475 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Antagonist activity at human CysLT1 receptor expressed in Syrian hamster AV12-664 cells assessed as decrease in LTD4-induced intracellular calcium le... |
Bioorg Med Chem Lett 27: 323-328 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.049 BindingDB Entry DOI: 10.7270/Q2DN471R |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50207407
(CHEMBL3936830)Show SMILES CC(=O)c1ccc(OCc2cccc(Oc3ccc(cn3)-c3nn[nH]n3)c2)c(Cl)c1O Show InChI InChI=1S/C21H16ClN5O4/c1-12(28)16-6-7-17(19(22)20(16)29)30-11-13-3-2-4-15(9-13)31-18-8-5-14(10-23-18)21-24-26-27-25-21/h2-10,29H,11H2,1H3,(H,24,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Positive allosteric modulation of recombinant human mGlu2 receptor expressed in hamster AV12 cells expressing EAAT1 assessed as potentiation of gluta... |
Bioorg Med Chem Lett 27: 323-328 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.049 BindingDB Entry DOI: 10.7270/Q2DN471R |
More data for this Ligand-Target Pair | |