Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359153
(US10220048, Compound AA63 | US10952992, No. AA63 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C28H29N3O4S2/c1-28(2,3)27(32)30-24(17-19-9-15-23(16-10-19)31-37(33,34)35)26-29-25(18-36-26)22-13-11-21(12-14-22)20-7-5-4-6-8-20/h4-16,18,24,31H,17H2,1-3H3,(H,30,32)(H,33,34,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359153
(US10220048, Compound AA63 | US10952992, No. AA63 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C28H29N3O4S2/c1-28(2,3)27(32)30-24(17-19-9-15-23(16-10-19)31-37(33,34)35)26-29-25(18-36-26)22-13-11-21(12-14-22)20-7-5-4-6-8-20/h4-16,18,24,31H,17H2,1-3H3,(H,30,32)(H,33,34,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359153
(US10220048, Compound AA63 | US10952992, No. AA63 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C28H29N3O4S2/c1-28(2,3)27(32)30-24(17-19-9-15-23(16-10-19)31-37(33,34)35)26-29-25(18-36-26)22-13-11-21(12-14-22)20-7-5-4-6-8-20/h4-16,18,24,31H,17H2,1-3H3,(H,30,32)(H,33,34,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359153
(US10220048, Compound AA63 | US10952992, No. AA63 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C28H29N3O4S2/c1-28(2,3)27(32)30-24(17-19-9-15-23(16-10-19)31-37(33,34)35)26-29-25(18-36-26)22-13-11-21(12-14-22)20-7-5-4-6-8-20/h4-16,18,24,31H,17H2,1-3H3,(H,30,32)(H,33,34,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |