Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359151
(US10220048, Compound AA61 | US10952992, No. AA61 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc2OCCOc2c1 |r| Show InChI InChI=1S/C24H27N3O6S2/c1-24(2,3)23(28)26-18(12-15-4-7-17(8-5-15)27-35(29,30)31)22-25-19(14-34-22)16-6-9-20-21(13-16)33-11-10-32-20/h4-9,13-14,18,27H,10-12H2,1-3H3,(H,26,28)(H,29,30,31)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC.
US Patent
| Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... |
US Patent US10220048 (2019)
BindingDB Entry DOI: 10.7270/Q2VT1VC9 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359151
(US10220048, Compound AA61 | US10952992, No. AA61 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc2OCCOc2c1 |r| Show InChI InChI=1S/C24H27N3O6S2/c1-24(2,3)23(28)26-18(12-15-4-7-17(8-5-15)27-35(29,30)31)22-25-19(14-34-22)16-6-9-20-21(13-16)33-11-10-32-20/h4-9,13-14,18,27H,10-12H2,1-3H3,(H,26,28)(H,29,30,31)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RV0SPJ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359151
(US10220048, Compound AA61 | US10952992, No. AA61 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc2OCCOc2c1 |r| Show InChI InChI=1S/C24H27N3O6S2/c1-24(2,3)23(28)26-18(12-15-4-7-17(8-5-15)27-35(29,30)31)22-25-19(14-34-22)16-6-9-20-21(13-16)33-11-10-32-20/h4-9,13-14,18,27H,10-12H2,1-3H3,(H,26,28)(H,29,30,31)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Non-limiting examples of the HPTPβ IC50 (μM) activity. |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2668HD5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase beta
(Homo sapiens (Human)) | BDBM359151
(US10220048, Compound AA61 | US10952992, No. AA61 |...)Show SMILES CC(C)(C)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1nc(cs1)-c1ccc2OCCOc2c1 |r| Show InChI InChI=1S/C24H27N3O6S2/c1-24(2,3)23(28)26-18(12-15-4-7-17(8-5-15)27-35(29,30)31)22-25-19(14-34-22)16-6-9-20-21(13-16)33-11-10-32-20/h4-9,13-14,18,27H,10-12H2,1-3H3,(H,26,28)(H,29,30,31)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC.
US Patent
| Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. |
US Patent US10952992 (2021)
BindingDB Entry DOI: 10.7270/Q2FR00R3 |
More data for this Ligand-Target Pair | |