Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 560.6 BDBM274980

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274980 (N2-(tert-butyl)-N8-(isoquinolin-1-ylmethyl)- 5-(3-...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1nccc2ccccc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-16-14-25-23(21-8-6-9-22(17-21)32(33,34)35)11-12-26(27(25)19-39)29(40)37-18-28-24-10-5-4-7-20(24)13-15-36-28/h4-13,15,17H,14,16,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	197	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair