Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169005
(US9079866, 406 | US9745328, Compound 406 | US98848...)Show SMILES CC(C)(C)OC(=O)N1CCC(COc2ncccc2-c2ccc(c(F)c2)-c2cnc(N)cn2)C1 Show InChI InChI=1S/C25H28FN5O3/c1-25(2,3)34-24(32)31-10-8-16(14-31)15-33-23-18(5-4-9-28-23)17-6-7-19(20(26)11-17)21-12-30-22(27)13-29-21/h4-7,9,11-13,16H,8,10,14-15H2,1-3H3,(H2,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this
Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM169005
(US9079866, 406 | US9745328, Compound 406 | US98848...)Show SMILES CC(C)(C)OC(=O)N1CCC(COc2ncccc2-c2ccc(c(F)c2)-c2cnc(N)cn2)C1 Show InChI InChI=1S/C25H28FN5O3/c1-25(2,3)34-24(32)31-10-8-16(14-31)15-33-23-18(5-4-9-28-23)17-6-7-19(20(26)11-17)21-12-30-22(27)13-29-21/h4-7,9,11-13,16H,8,10,14-15H2,1-3H3,(H2,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169005
(US9079866, 406 | US9745328, Compound 406 | US98848...)Show SMILES CC(C)(C)OC(=O)N1CCC(COc2ncccc2-c2ccc(c(F)c2)-c2cnc(N)cn2)C1 Show InChI InChI=1S/C25H28FN5O3/c1-25(2,3)34-24(32)31-10-8-16(14-31)15-33-23-18(5-4-9-28-23)17-6-7-19(20(26)11-17)21-12-30-22(27)13-29-21/h4-7,9,11-13,16H,8,10,14-15H2,1-3H3,(H2,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this
Ligand-Target Pair | |