Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-C chemokine receptor type 9
(Homo sapiens (Human)) | BDBM393495
(US9969687, Compound 65)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccc[n+]([O-])c3)C(=O)c12 Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)16-6-8-17(9-7-16)34(32,33)26-19-11-10-18(25)20-21(19)23(30)28(22(20)29)14-15-5-4-12-27(31)13-15/h4-13,26H,14H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Norgine Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubate... |
J Med Chem 59: 3098-111 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01840 BindingDB Entry DOI: 10.7270/Q28918WJ |
More data for this Ligand-Target Pair | |
C-C chemokine receptor type 9
(Homo sapiens (Human)) | BDBM393495
(US9969687, Compound 65)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccc[n+]([O-])c3)C(=O)c12 Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)16-6-8-17(9-7-16)34(32,33)26-19-11-10-18(25)20-21(19)23(30)28(22(20)29)14-15-5-4-12-27(31)13-15/h4-13,26H,14H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Norgine Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed C... |
J Med Chem 59: 3098-111 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01840 BindingDB Entry DOI: 10.7270/Q28918WJ |
More data for this Ligand-Target Pair | |
C-C chemokine receptor type 9
(Homo sapiens (Human)) | BDBM393495
(US9969687, Compound 65)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccc[n+]([O-])c3)C(=O)c12 Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)16-6-8-17(9-7-16)34(32,33)26-19-11-10-18(25)20-21(19)23(30)28(22(20)29)14-15-5-4-12-27(31)13-15/h4-13,26H,14H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Norgine Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intrace... |
J Med Chem 59: 3098-111 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01840 BindingDB Entry DOI: 10.7270/Q28918WJ |
More data for this Ligand-Target Pair | |
C-C chemokine receptor type 9
(Homo sapiens (Human)) | BDBM393495
(US9969687, Compound 65)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccc[n+]([O-])c3)C(=O)c12 Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)16-6-8-17(9-7-16)34(32,33)26-19-11-10-18(25)20-21(19)23(30)28(22(20)29)14-15-5-4-12-27(31)13-15/h4-13,26H,14H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in... |
J Med Chem 52: 2652-5 (2009)
BindingDB Entry DOI: 10.7270/Q28W3GNH |
More data for this Ligand-Target Pair | |