Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM286235
(Compound 1459 | US9518026, Example 28 | US9956214,...)Show SMILES CC(C)(C)n1cc(C(N)=O)c(n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C15H18N6O/c1-15(2,3)21-7-10(14(17)22)12(20-21)8-4-5-9-11(6-8)18-19-13(9)16/h4-7H,1-3H3,(H2,17,22)(H3,16,18,19) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM286235
(Compound 1459 | US9518026, Example 28 | US9956214,...)Show SMILES CC(C)(C)n1cc(C(N)=O)c(n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C15H18N6O/c1-15(2,3)21-7-10(14(17)22)12(20-21)8-4-5-9-11(6-8)18-19-13(9)16/h4-7H,1-3H3,(H2,17,22)(H3,16,18,19) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM286235
(Compound 1459 | US9518026, Example 28 | US9956214,...)Show SMILES CC(C)(C)n1cc(C(N)=O)c(n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C15H18N6O/c1-15(2,3)21-7-10(14(17)22)12(20-21)8-4-5-9-11(6-8)18-19-13(9)16/h4-7H,1-3H3,(H2,17,22)(H3,16,18,19) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM286235
(Compound 1459 | US9518026, Example 28 | US9956214,...)Show SMILES CC(C)(C)n1cc(C(N)=O)c(n1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C15H18N6O/c1-15(2,3)21-7-10(14(17)22)12(20-21)8-4-5-9-11(6-8)18-19-13(9)16/h4-7H,1-3H3,(H2,17,22)(H3,16,18,19) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |