Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50200562
(CHEMBL3985876 | US9518026, Example 81 | US9956214,...)Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1 Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-6-8-16-13(10-14)7-9-17(25-16)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200562
(CHEMBL3985876 | US9518026, Example 81 | US9956214,...)Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1 Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-6-8-16-13(10-14)7-9-17(25-16)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l... |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200562
(CHEMBL3985876 | US9518026, Example 81 | US9956214,...)Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1 Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-6-8-16-13(10-14)7-9-17(25-16)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50200562
(CHEMBL3985876 | US9518026, Example 81 | US9956214,...)Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1 Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-6-8-16-13(10-14)7-9-17(25-16)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50200562
(CHEMBL3985876 | US9518026, Example 81 | US9956214,...)Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1 Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-6-8-16-13(10-14)7-9-17(25-16)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50200562
(CHEMBL3985876 | US9518026, Example 81 | US9956214,...)Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1 Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-6-8-16-13(10-14)7-9-17(25-16)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assay |
Bioorg Med Chem Lett 26: 5487-5491 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR |
More data for this Ligand-Target Pair | |