Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cathepsin K
(Homo sapiens (Human)) | BDBM19868
((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(1H-tetraazol-...)Show SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)-c1nnn[nH]1 |r| Show InChI InChI=1S/C21H22N6O/c1-14(2)12-19(21(28)23-11-10-22)18-5-3-4-17(13-18)15-6-8-16(9-7-15)20-24-26-27-25-20/h3-9,13-14,19H,11-12H2,1-2H3,(H,23,28)(H,24,25,26,27)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.58E+3 | n/a | n/a | n/a | n/a | 5.5 | 22 |
Merck Frosst Centre for Therapeutic Research
| Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ... |
J Med Chem 46: 3709-27 (2003)
Article DOI: 10.1021/jm0301078 BindingDB Entry DOI: 10.7270/Q2513WH4 |
More data for this Ligand-Target Pair | |
Cathepsin S
(Homo sapiens (Human)) | BDBM19868
((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(1H-tetraazol-...)Show SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)-c1nnn[nH]1 |r| Show InChI InChI=1S/C21H22N6O/c1-14(2)12-19(21(28)23-11-10-22)18-5-3-4-17(13-18)15-6-8-16(9-7-15)20-24-26-27-25-20/h3-9,13-14,19H,11-12H2,1-2H3,(H,23,28)(H,24,25,26,27)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
| Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ... |
J Med Chem 46: 3709-27 (2003)
Article DOI: 10.1021/jm0301078 BindingDB Entry DOI: 10.7270/Q2513WH4 |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM19868
((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(1H-tetraazol-...)Show SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)-c1nnn[nH]1 |r| Show InChI InChI=1S/C21H22N6O/c1-14(2)12-19(21(28)23-11-10-22)18-5-3-4-17(13-18)15-6-8-16(9-7-15)20-24-26-27-25-20/h3-9,13-14,19H,11-12H2,1-2H3,(H,23,28)(H,24,25,26,27)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
| Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ... |
J Med Chem 46: 3709-27 (2003)
Article DOI: 10.1021/jm0301078 BindingDB Entry DOI: 10.7270/Q2513WH4 |
More data for this Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM19868
((2R)-N-(Cyanomethyl)-4-methyl-2-[4 -(1H-tetraazol-...)Show SMILES CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1ccc(cc1)-c1nnn[nH]1 |r| Show InChI InChI=1S/C21H22N6O/c1-14(2)12-19(21(28)23-11-10-22)18-5-3-4-17(13-18)15-6-8-16(9-7-15)20-24-26-27-25-20/h3-9,13-14,19H,11-12H2,1-2H3,(H,23,28)(H,24,25,26,27)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
| Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ... |
J Med Chem 46: 3709-27 (2003)
Article DOI: 10.1021/jm0301078 BindingDB Entry DOI: 10.7270/Q2513WH4 |
More data for this Ligand-Target Pair | |