Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 712.8 BDBM50190510

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 8 (Homo sapiens (Human))	BDBM50190510 (CHEMBL3827271) Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O |r| Show InChI InChI=1S/C31H56N10O9/c1-18(2)16-22-26(45)35-15-11-24(42)37-19(8-3-5-12-32)27(46)41-23(17-25(43)44)30(49)39-20(9-4-6-13-33)28(47)38-21(29(48)40-22)10-7-14-36-31(34)50/h18-23H,3-17,32-33H2,1-2H3,(H,35,45)(H,37,42)(H,38,47)(H,39,49)(H,40,48)(H,41,46)(H,43,44)(H3,34,36,50)/t19-,20-,21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...				Bioorg Med Chem 24: 4032-4037 (2016) Article DOI: 10.1016/j.bmc.2016.06.042 BindingDB Entry DOI: 10.7270/Q2ST7RS3
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