Found 14 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ measured after 90 mins by scintillation counting ... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ measured after 90 mins by scintillation counting ... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]propionyl-pNPY from human Y2 receptor expressed in CHO cells measured after 2 hrs by microbeta liquid scintillation counting anal... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]propionyl-pNPY from human Y2 receptor expressed in CHO cells measured after 2 hrs by microbeta liquid scintillation counting anal... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]propionyl-pNPY from human Y5 receptor expressed in human HEC1B cells |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Displacement of [3H]propionyl-pNPY from human Y5 receptor expressed in human HEC1B cells |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 275 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 280 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 166 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 437 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50542856
(CHEMBL4639709)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 440 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description Agonist activity at human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as intracellular calcium mobilization measured for 43 ... |
J Med Chem 63: 8198-8215 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00426 BindingDB Entry DOI: 10.7270/Q22R3W7V |
More data for this Ligand-Target Pair | |