Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50535856
(CHEMBL4581302)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C74H109N19O16/c1-40(2)34-57(69(106)84-42(5)64(101)89-55(62(76)99)36-44-16-24-48(94)25-17-44)92-67(104)53(13-10-32-82-73(78)79)87-71(108)59(38-46-20-28-50(96)29-21-46)86-61(98)15-9-7-8-12-52(75)66(103)91-60(39-47-22-30-51(97)31-23-47)72(109)88-54(14-11-33-83-74(80)81)68(105)93-58(35-41(3)4)70(107)85-43(6)65(102)90-56(63(77)100)37-45-18-26-49(95)27-19-45/h16-31,40-43,52-60,94-97H,7-15,32-39,75H2,1-6H3,(H2,76,99)(H2,77,100)(H,84,106)(H,85,107)(H,86,98)(H,87,108)(H,88,109)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H4,78,79,82)(H4,80,81,83)/t42-,43-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of [3H](2R,7R)-10 from human NPY Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ after 90 mins in presence of sodium-free HE... |
J Med Chem 59: 6045-58 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00309
BindingDB Entry DOI: 10.7270/Q25T3Q08 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50535856
(CHEMBL4581302)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C74H109N19O16/c1-40(2)34-57(69(106)84-42(5)64(101)89-55(62(76)99)36-44-16-24-48(94)25-17-44)92-67(104)53(13-10-32-82-73(78)79)87-71(108)59(38-46-20-28-50(96)29-21-46)86-61(98)15-9-7-8-12-52(75)66(103)91-60(39-47-22-30-51(97)31-23-47)72(109)88-54(14-11-33-83-74(80)81)68(105)93-58(35-41(3)4)70(107)85-43(6)65(102)90-56(63(77)100)37-45-18-26-49(95)27-19-45/h16-31,40-43,52-60,94-97H,7-15,32-39,75H2,1-6H3,(H2,76,99)(H2,77,100)(H,84,106)(H,85,107)(H,86,98)(H,87,108)(H,88,109)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H4,78,79,82)(H4,80,81,83)/t42-,43-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting |
J Med Chem 59: 6045-58 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00309
BindingDB Entry DOI: 10.7270/Q25T3Q08 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50535856
(CHEMBL4581302)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C74H109N19O16/c1-40(2)34-57(69(106)84-42(5)64(101)89-55(62(76)99)36-44-16-24-48(94)25-17-44)92-67(104)53(13-10-32-82-73(78)79)87-71(108)59(38-46-20-28-50(96)29-21-46)86-61(98)15-9-7-8-12-52(75)66(103)91-60(39-47-22-30-51(97)31-23-47)72(109)88-54(14-11-33-83-74(80)81)68(105)93-58(35-41(3)4)70(107)85-43(6)65(102)90-56(63(77)100)37-45-18-26-49(95)27-19-45/h16-31,40-43,52-60,94-97H,7-15,32-39,75H2,1-6H3,(H2,76,99)(H2,77,100)(H,84,106)(H,85,107)(H,86,98)(H,87,108)(H,88,109)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H4,78,79,82)(H4,80,81,83)/t42-,43-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]propionyl-pNPY from human NPY Y2 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ after 90 mins by liquid scintillation c... |
J Med Chem 59: 6045-58 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00309
BindingDB Entry DOI: 10.7270/Q25T3Q08 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50535856
(CHEMBL4581302)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C74H109N19O16/c1-40(2)34-57(69(106)84-42(5)64(101)89-55(62(76)99)36-44-16-24-48(94)25-17-44)92-67(104)53(13-10-32-82-73(78)79)87-71(108)59(38-46-20-28-50(96)29-21-46)86-61(98)15-9-7-8-12-52(75)66(103)91-60(39-47-22-30-51(97)31-23-47)72(109)88-54(14-11-33-83-74(80)81)68(105)93-58(35-41(3)4)70(107)85-43(6)65(102)90-56(63(77)100)37-45-18-26-49(95)27-19-45/h16-31,40-43,52-60,94-97H,7-15,32-39,75H2,1-6H3,(H2,76,99)(H2,77,100)(H,84,106)(H,85,107)(H,86,98)(H,87,108)(H,88,109)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H4,78,79,82)(H4,80,81,83)/t42-,43-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]propionyl-pNPY from human NPY Y5 receptor expressed in human HEC1b cells after 120 mins by liquid scintillation counting |
J Med Chem 59: 6045-58 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00309
BindingDB Entry DOI: 10.7270/Q25T3Q08 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50535856
(CHEMBL4581302)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C74H109N19O16/c1-40(2)34-57(69(106)84-42(5)64(101)89-55(62(76)99)36-44-16-24-48(94)25-17-44)92-67(104)53(13-10-32-82-73(78)79)87-71(108)59(38-46-20-28-50(96)29-21-46)86-61(98)15-9-7-8-12-52(75)66(103)91-60(39-47-22-30-51(97)31-23-47)72(109)88-54(14-11-33-83-74(80)81)68(105)93-58(35-41(3)4)70(107)85-43(6)65(102)90-56(63(77)100)37-45-18-26-49(95)27-19-45/h16-31,40-43,52-60,94-97H,7-15,32-39,75H2,1-6H3,(H2,76,99)(H2,77,100)(H,84,106)(H,85,107)(H,86,98)(H,87,108)(H,88,109)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H4,78,79,82)(H4,80,81,83)/t42-,43-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Agonist activity at human NPY Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as induction of calcium mobilization by aequorin l... |
J Med Chem 59: 6045-58 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00309
BindingDB Entry DOI: 10.7270/Q25T3Q08 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50535856
(CHEMBL4581302)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C74H109N19O16/c1-40(2)34-57(69(106)84-42(5)64(101)89-55(62(76)99)36-44-16-24-48(94)25-17-44)92-67(104)53(13-10-32-82-73(78)79)87-71(108)59(38-46-20-28-50(96)29-21-46)86-61(98)15-9-7-8-12-52(75)66(103)91-60(39-47-22-30-51(97)31-23-47)72(109)88-54(14-11-33-83-74(80)81)68(105)93-58(35-41(3)4)70(107)85-43(6)65(102)90-56(63(77)100)37-45-18-26-49(95)27-19-45/h16-31,40-43,52-60,94-97H,7-15,32-39,75H2,1-6H3,(H2,76,99)(H2,77,100)(H,84,106)(H,85,107)(H,86,98)(H,87,108)(H,88,109)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H4,78,79,82)(H4,80,81,83)/t42-,43-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Agonist activity at human NPY Y4 receptor expressed in HEK293 cells co-expressing CRE-Luc gene assessed as inhibition of forskolin stimulated lucifer... |
J Med Chem 59: 6045-58 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00309
BindingDB Entry DOI: 10.7270/Q25T3Q08 |
More data for this
Ligand-Target Pair | |