Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 637.6 BDBM50015240

Wt: 637.6 BDBM50015246

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteasome subunit beta type-7 (Homo sapiens (Human))	BDBM50015246 (CHEMBL3262765) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C[C@@H](NC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C35H38F3N3O5/c1-22(2)18-28(31(43)34(3)21-46-34)41-33(45)29(19-23-10-6-4-7-11-23)39-30(42)20-27(24-12-8-5-9-13-24)40-32(44)25-14-16-26(17-15-25)35(36,37)38/h4-17,22,27-29H,18-21H2,1-3H3,(H,39,42)(H,40,44)(H,41,45)/t27-,28+,29+,34-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method				Bioorg Med Chem 22: 2955-65 (2014) Article DOI: 10.1016/j.bmc.2014.04.011 BindingDB Entry DOI: 10.7270/Q24J0GP4
					More data for this Ligand-Target Pair
Proteasome subunit beta type-7 (Homo sapiens (Human))	BDBM50015240 (CHEMBL3262756) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C35H38F3N3O5/c1-22(2)18-28(31(43)34(3)21-46-34)41-33(45)29(19-23-10-6-4-7-11-23)39-30(42)20-27(24-12-8-5-9-13-24)40-32(44)25-14-16-26(17-15-25)35(36,37)38/h4-17,22,27-29H,18-21H2,1-3H3,(H,39,42)(H,40,44)(H,41,45)/t27?,28-,29-,34+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method				Bioorg Med Chem 22: 2955-65 (2014) Article DOI: 10.1016/j.bmc.2014.04.011 BindingDB Entry DOI: 10.7270/Q24J0GP4
					More data for this Ligand-Target Pair