Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50017212
(CHEMBL3287671 | US10099993, Compound 20)Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2)C(O)=O)c(C)c1O Show InChI InChI=1S/C23H28O6/c1-15(2)14-20(24)19-10-11-21(16(3)22(19)25)29-13-5-4-12-28-18-8-6-17(7-9-18)23(26)27/h6-11,15,25H,4-5,12-14H2,1-3H3,(H,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a |
Sanford-Burnham Medical Research Institute
Curated by ChEMBL
| Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated... |
J Med Chem 57: 4154-72 (2014)
Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Homo sapiens (Human)) | BDBM50017212
(CHEMBL3287671 | US10099993, Compound 20)Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2)C(O)=O)c(C)c1O Show InChI InChI=1S/C23H28O6/c1-15(2)14-20(24)19-10-11-21(16(3)22(19)25)29-13-5-4-12-28-18-8-6-17(7-9-18)23(26)27/h6-11,15,25H,4-5,12-14H2,1-3H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
US Patent
| |
US Patent US10099993 (2018)
BindingDB Entry DOI: 10.7270/Q2Z89FFP |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50017212
(CHEMBL3287671 | US10099993, Compound 20)Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2)C(O)=O)c(C)c1O Show InChI InChI=1S/C23H28O6/c1-15(2)14-20(24)19-10-11-21(16(3)22(19)25)29-13-5-4-12-28-18-8-6-17(7-9-18)23(26)27/h6-11,15,25H,4-5,12-14H2,1-3H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | n/a | n/a | 122 | n/a | n/a | 7.3 | 25 |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
US Patent
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10099993 (2018)
BindingDB Entry DOI: 10.7270/Q2Z89FFP |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50017212
(CHEMBL3287671 | US10099993, Compound 20)Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2)C(O)=O)c(C)c1O Show InChI InChI=1S/C23H28O6/c1-15(2)14-20(24)19-10-11-21(16(3)22(19)25)29-13-5-4-12-28-18-8-6-17(7-9-18)23(26)27/h6-11,15,25H,4-5,12-14H2,1-3H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 122 | n/a | n/a | n/a | n/a |
Sanford-Burnham Medical Research Institute
Curated by ChEMBL
| Assay Description Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated... |
J Med Chem 57: 4154-72 (2014)
Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9 |
More data for this Ligand-Target Pair | |