Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
PAS domain-containing serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM463501
(2-(1H-Indol-5-yl)-3-(isopropyl(methyl)amino)quinox...)Show SMILES CC(C)N(C)c1nc2cc(ccc2nc1-c1ccc2[nH]ccc2c1)C(O)=O Show InChI InChI=1S/C21H20N4O2/c1-12(2)25(3)20-19(14-4-6-16-13(10-14)8-9-22-16)23-17-7-5-15(21(26)27)11-18(17)24-20/h4-12,22H,1-3H3,(H,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BioEnergenix LLC
US Patent
| Assay Description Purified PASK (UniProt # Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) i... |
US Patent US10781185 (2020)
BindingDB Entry DOI: 10.7270/Q2DR2ZKW |
More data for this Ligand-Target Pair | |
PAS domain-containing serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM463501
(2-(1H-Indol-5-yl)-3-(isopropyl(methyl)amino)quinox...)Show SMILES CC(C)N(C)c1nc2cc(ccc2nc1-c1ccc2[nH]ccc2c1)C(O)=O Show InChI InChI=1S/C21H20N4O2/c1-12(2)25(3)20-19(14-4-6-16-13(10-14)8-9-22-16)23-17-7-5-15(21(26)27)11-18(17)24-20/h4-12,22H,1-3H3,(H,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BioEnergenix LLC
US Patent
| Assay Description Compound screening was done via the following method. 10 mM stock solution of test compound in DMSO was prepared by dissolving test compound in DMSO ... |
US Patent US10781185 (2020)
BindingDB Entry DOI: 10.7270/Q2DR2ZKW |
More data for this Ligand-Target Pair | |
PAS domain-containing serine/threonine-protein kinase [879-1323]
(Homo sapiens (Human)) | BDBM463501
(2-(1H-Indol-5-yl)-3-(isopropyl(methyl)amino)quinox...)Show SMILES CC(C)N(C)c1nc2cc(ccc2nc1-c1ccc2[nH]ccc2c1)C(O)=O Show InChI InChI=1S/C21H20N4O2/c1-12(2)25(3)20-19(14-4-6-16-13(10-14)8-9-22-16)23-17-7-5-15(21(26)27)11-18(17)24-20/h4-12,22H,1-3H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Purified PASK (UniProt #Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) is... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2D79FN2 |
More data for this Ligand-Target Pair | |
PAS domain-containing serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM463501
(2-(1H-Indol-5-yl)-3-(isopropyl(methyl)amino)quinox...)Show SMILES CC(C)N(C)c1nc2cc(ccc2nc1-c1ccc2[nH]ccc2c1)C(O)=O Show InChI InChI=1S/C21H20N4O2/c1-12(2)25(3)20-19(14-4-6-16-13(10-14)8-9-22-16)23-17-7-5-15(21(26)27)11-18(17)24-20/h4-12,22H,1-3H3,(H,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The aim of the FRET assay is to determine the inhibition potential of test compounds on targeted kinase. This assay platform provides a homogenous sc... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2D79FN2 |
More data for this Ligand-Target Pair | |