Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM148270
(US8962630, 80)Show SMILES CC(C)N1CCC(CC1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C27H37N7O/c1-18(2)33-13-11-19(12-14-33)20-9-10-24(28-16-20)30-27-29-17-21-15-23(26(35)32(3)4)34(25(21)31-27)22-7-5-6-8-22/h9-10,15-19,22H,5-8,11-14H2,1-4H3,(H,28,29,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assay was run under the conditions identical to that for CDK1/cyclin B except 0.25 nM CDK1/cyclin B was replaced with 0.3 nM CDK2/cyclin A. A 384... |
US Patent US8962630 (2015)
BindingDB Entry DOI: 10.7270/Q2RJ4H6C |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM148270
(US8962630, 80)Show SMILES CC(C)N1CCC(CC1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C27H37N7O/c1-18(2)33-13-11-19(12-14-33)20-9-10-24(28-16-20)30-27-29-17-21-15-23(26(35)32(3)4)34(25(21)31-27)22-7-5-6-8-22/h9-10,15-19,22H,5-8,11-14H2,1-4H3,(H,28,29,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
A 384-well microtiter IMAP-FPT (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The ... |
US Patent US8962630 (2015)
BindingDB Entry DOI: 10.7270/Q2RJ4H6C |
More data for this
Ligand-Target Pair | |