Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM148260
(US8962630, 70)Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)nn1 Show InChI InChI=1S/C25H35N9O/c1-17(2)32-11-13-33(14-12-32)22-10-9-21(29-30-22)27-25-26-16-18-15-20(24(35)31(3)4)34(23(18)28-25)19-7-5-6-8-19/h9-10,15-17,19H,5-8,11-14H2,1-4H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description The assay was run under the conditions identical to that for CDK1/cyclin B except 0.25 nM CDK1/cyclin B was replaced with 0.3 nM CDK2/cyclin A. A 384... |
US Patent US8962630 (2015)
BindingDB Entry DOI: 10.7270/Q2RJ4H6C |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM148260
(US8962630, 70)Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)nn1 Show InChI InChI=1S/C25H35N9O/c1-17(2)32-11-13-33(14-12-32)22-10-9-21(29-30-22)27-25-26-16-18-15-20(24(35)31(3)4)34(23(18)28-25)19-7-5-6-8-19/h9-10,15-17,19H,5-8,11-14H2,1-4H3,(H,26,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description A 384-well microtiter IMAP-FPT (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The ... |
US Patent US8962630 (2015)
BindingDB Entry DOI: 10.7270/Q2RJ4H6C |
More data for this Ligand-Target Pair | |