Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM444524
(US10662186, Compound 45 | US10988476, Compound I-4...)Show SMILES CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 Show InChI InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.14 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM444524
(US10662186, Compound 45 | US10988476, Compound I-4...)Show SMILES CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 Show InChI InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.14 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM444524
(US10662186, Compound 45 | US10988476, Compound I-4...)Show SMILES CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 Show InChI InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 22.7 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM444524
(US10662186, Compound 45 | US10988476, Compound I-4...)Show SMILES CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 Show InChI InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 22.7 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM444524
(US10662186, Compound 45 | US10988476, Compound I-4...)Show SMILES CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 Show InChI InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM444524
(US10662186, Compound 45 | US10988476, Compound I-4...)Show SMILES CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 Show InChI InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |