Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50148730
(CHEMBL3770546 | US9518026, Example 67 | US9956214,...)Show SMILES CC(C)Oc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C20H25N5O2/c1-11(2)27-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)20(3,4)5/h6-11H,21H2,1-5H3,(H2,22,26) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148730
(CHEMBL3770546 | US9518026, Example 67 | US9956214,...)Show SMILES CC(C)Oc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C20H25N5O2/c1-11(2)27-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)20(3,4)5/h6-11H,21H2,1-5H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148730
(CHEMBL3770546 | US9518026, Example 67 | US9956214,...)Show SMILES CC(C)Oc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C20H25N5O2/c1-11(2)27-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)20(3,4)5/h6-11H,21H2,1-5H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of Toxoplasma gondii CDPK1 assessed as ATP consumption using (Biotin-C6-PLARTLSVAGLPGKK) as substrate after 90 mins by luciferase reporter... |
ACS Med Chem Lett 6: 1184-1189 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00319 BindingDB Entry DOI: 10.7270/Q2NK3GXD |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50148730
(CHEMBL3770546 | US9518026, Example 67 | US9956214,...)Show SMILES CC(C)Oc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C20H25N5O2/c1-11(2)27-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)20(3,4)5/h6-11H,21H2,1-5H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| US Patent
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM50148730
(CHEMBL3770546 | US9518026, Example 67 | US9956214,...)Show SMILES CC(C)Oc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C Show InChI InChI=1S/C20H25N5O2/c1-11(2)27-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)20(3,4)5/h6-11H,21H2,1-5H3,(H2,22,26) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| US Patent
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |