Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50044466
(CHEMBL3357461)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CCC(C3)O4)c2)ncc1Cl Show InChI InChI=1S/C27H31ClN6O4S/c1-17(2)39(36,37)24-9-4-3-8-23(24)32-26-22(28)13-29-27(33-26)31-19-7-5-6-18(12-19)30-25(35)16-34-14-20-10-11-21(15-34)38-20/h3-9,12-13,17,20-21H,10-11,14-16H2,1-2H3,(H,30,35)(H2,29,31,32,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) after 60 mins by ELISA |
J Med Chem 58: 197-211 (2015)
Article DOI: 10.1021/jm5005144 BindingDB Entry DOI: 10.7270/Q2FB54MQ |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044466
(CHEMBL3357461)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CCC(C3)O4)c2)ncc1Cl Show InChI InChI=1S/C27H31ClN6O4S/c1-17(2)39(36,37)24-9-4-3-8-23(24)32-26-22(28)13-29-27(33-26)31-19-7-5-6-18(12-19)30-25(35)16-34-14-20-10-11-21(15-34)38-20/h3-9,12-13,17,20-21H,10-11,14-16H2,1-2H3,(H,30,35)(H2,29,31,32,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA |
J Med Chem 58: 197-211 (2015)
Article DOI: 10.1021/jm5005144 BindingDB Entry DOI: 10.7270/Q2FB54MQ |
More data for this Ligand-Target Pair | |