Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM380759
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1)C1=CCOCC1 |t:37| Show InChI InChI=1S/C27H25ClF2N6O2/c1-14(2)35-22-20(31-25(35)17-8-10-38-11-9-17)27(37)36(21(22)16-4-6-18(28)7-5-16)19-12-15(3)24-32-33-26(23(29)30)34(24)13-19/h4-8,12-14,21,23H,9-11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM380759
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1)C1=CCOCC1 |t:37| Show InChI InChI=1S/C27H25ClF2N6O2/c1-14(2)35-22-20(31-25(35)17-8-10-38-11-9-17)27(37)36(21(22)16-4-6-18(28)7-5-16)19-12-15(3)24-32-33-26(23(29)30)34(24)13-19/h4-8,12-14,21,23H,9-11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 2
(Homo sapiens (Human)) | BDBM380759
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1)C1=CCOCC1 |t:37| Show InChI InChI=1S/C27H25ClF2N6O2/c1-14(2)35-22-20(31-25(35)17-8-10-38-11-9-17)27(37)36(21(22)16-4-6-18(28)7-5-16)19-12-15(3)24-32-33-26(23(29)30)34(24)13-19/h4-8,12-14,21,23H,9-11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM380759
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1)C1=CCOCC1 |t:37| Show InChI InChI=1S/C27H25ClF2N6O2/c1-14(2)35-22-20(31-25(35)17-8-10-38-11-9-17)27(37)36(21(22)16-4-6-18(28)7-5-16)19-12-15(3)24-32-33-26(23(29)30)34(24)13-19/h4-8,12-14,21,23H,9-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |