Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM380663
(6-(4-Chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1=CCN(C)CC1 |t:35| Show InChI InChI=1S/C28H30ClN7O/c1-16(2)35-25-23(30-27(35)20-10-12-33(5)13-11-20)28(37)36(24(25)19-6-8-21(29)9-7-19)22-14-17(3)26-32-31-18(4)34(26)15-22/h6-10,14-16,24H,11-13H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM380663
(6-(4-Chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1=CCN(C)CC1 |t:35| Show InChI InChI=1S/C28H30ClN7O/c1-16(2)35-25-23(30-27(35)20-10-12-33(5)13-11-20)28(37)36(24(25)19-6-8-21(29)9-7-19)22-14-17(3)26-32-31-18(4)34(26)15-22/h6-10,14-16,24H,11-13H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 2
(Homo sapiens (Human)) | BDBM380663
(6-(4-Chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1=CCN(C)CC1 |t:35| Show InChI InChI=1S/C28H30ClN7O/c1-16(2)35-25-23(30-27(35)20-10-12-33(5)13-11-20)28(37)36(24(25)19-6-8-21(29)9-7-19)22-14-17(3)26-32-31-18(4)34(26)15-22/h6-10,14-16,24H,11-13H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM380663
(6-(4-Chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1=CCN(C)CC1 |t:35| Show InChI InChI=1S/C28H30ClN7O/c1-16(2)35-25-23(30-27(35)20-10-12-33(5)13-11-20)28(37)36(24(25)19-6-8-21(29)9-7-19)22-14-17(3)26-32-31-18(4)34(26)15-22/h6-10,14-16,24H,11-13H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ... |
Cancer Res 66: 8715-21 (2006)
BindingDB Entry DOI: 10.7270/Q2TM7DFQ |
More data for this
Ligand-Target Pair | |