Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 511.5 BDBM530650

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM530650 (WO2022076495, EXAMPLE 81) Show SMILES CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1 |wU:27.29,wD:27.30,(.14,1.73,;1.65,1.41,;2.68,2.55,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;6.26,-2.07,;4.92,-2.84,;3.59,-2.07,;2.13,-2.55,;1.65,-4.01,;2.68,-5.16,;2.2,-6.62,;3.23,-7.77,;2.76,-9.23,;3.79,-10.38,;1.25,-9.55,;.7,-6.94,;-.33,-5.8,;.14,-4.33,;-.89,-3.19,;1.22,-1.3,;-.32,-1.3,;7.59,.24,;8.93,-.53,;7.59,1.78,;8.93,2.55,;9.55,1.14,;8.02,3.79,;8.93,5.04,;10.39,4.56,;10.71,6.07,;11.92,4.4,;10.39,3.02,)| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022076495	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product 13Ci8-triolein (13C-l,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ZP4981
					More data for this Ligand-Target Pair