Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase kinase kinase 12
(Homo sapiens (Human)) | BDBM50271256
(CHEMBL3718750)Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc(N)c(Cl)c1 Show InChI InChI=1S/C19H26ClN5O/c1-12(2)25-18(13-3-5-24(6-4-13)15-10-26-11-15)8-17(23-25)14-7-16(20)19(21)22-9-14/h7-9,12-13,15H,3-6,10-11H2,1-2H3,(H2,21,22) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Co., Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4... |
J Med Chem 60: 8083-8102 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00843
BindingDB Entry DOI: 10.7270/Q2639S7K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 12
(Homo sapiens (Human)) | BDBM50271256
(CHEMBL3718750)Show SMILES CC(C)n1nc(cc1C1CCN(CC1)C1COC1)-c1cnc(N)c(Cl)c1 Show InChI InChI=1S/C19H26ClN5O/c1-12(2)25-18(13-3-5-24(6-4-13)15-10-26-11-15)8-17(23-25)14-7-16(20)19(21)22-9-14/h7-9,12-13,15H,3-6,10-11H2,1-2H3,(H2,21,22) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas... |
J Med Chem 60: 8083-8102 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00843
BindingDB Entry DOI: 10.7270/Q2639S7K |
More data for this
Ligand-Target Pair | |