Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 528.5 BDBM275008

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275008 (N2-(tert-butyl)-N8-(2-(isoxazol-5-yl)propyl)- 5-(3...) Show SMILES CC(CNC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C)c1ccno1 Show InChI InChI=1S/C28H31F3N4O3/c1-17(24-10-12-33-38-24)15-32-25(36)22-9-8-20(18-6-5-7-19(14-18)28(29,30)31)21-11-13-35(16-23(21)22)26(37)34-27(2,3)4/h5-10,12,14,17H,11,13,15-16H2,1-4H3,(H,32,36)(H,34,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair