Found 14 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451821
(US10710980, Example 50 | US10947218, Example 50)Show SMILES CC(F)(F)CN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:9.12,27.30,wD:30.34,7.7,(9.23,-2.35,;8.56,-3.62,;9.33,-4.95,;9.83,-3.25,;7.29,-3.62,;6.52,-2.29,;7.29,-.95,;6.26,.19,;5.01,1.1,;4.85,-.44,;5.01,-1.97,;3.52,.33,;2.18,-.44,;.85,.33,;.85,1.87,;2.18,2.64,;3.52,1.87,;-.48,2.64,;-.48,4.18,;-1.82,4.95,;-3.15,4.18,;-4.48,4.95,;-3.15,2.64,;-1.82,1.87,;-4.48,1.87,;-5.82,2.64,;-4.48,.33,;-5.82,-.44,;-5.95,-1.97,;-7.35,-2.62,;-8.61,-1.74,;-9.83,-2.35,;-8.48,-.2,;-7.08,.45,)| Show InChI InChI=1S/C26H32F2N4O2/c1-25(27,28)14-32-13-19-11-26(19,15-32)18-4-2-16(3-5-18)17-10-22(23(29)30-12-17)24(34)31-20-6-8-21(33)9-7-20/h2-5,10,12,19-21,33H,6-9,11,13-15H2,1H3,(H2,29,30)(H,31,34)/t19-,20-,21-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |